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Mechanical Engineering


Tarek Shazly

Assistant Professor

Tarek Shazly E-mail: shazly@cec.sc.edu
Phone: 803.777.4678
Fax: 803.777.0106
Office: 300 Main Street
Room A113
Columbia, SC 29208

Diverse interactions between soft tissues and implanted biomaterials directly influence the success or failure of therapeutic interventions. The nature, time course and extent of governing interactions depend strongly on both the tissues and materials involved in a given clinical scenario. Despite extreme variations in tissue surface morphologies, mechanics and chemistries, these and other differences are often overlooked in biomaterials engineering. The research in Dr. Shazly’s lab is focused on defining and characterizing relevant tissue properties for clinical applications and rationally designing polymeric biomaterials that leverage local biology to enhance therapeutic gain. His specific interests include physiological mechanical testing of soft matter, mechanical modeling, multiphysics-based computational modeling, tissue-material adhesion and tissue scaffold engineering.


Education

  • Ph.D., Bio- and Polymeric Materials Science and Engineering, Massachusetts Institute of Technology, 2009
  • S.M., Materials Science and Engineering, Massachusetts Institute of Technology, 2007
  • M.S., Bioengineering, Georgia Institute of Technology, 2004
  • B.S., Mechanical Engineering, Georgia Institute of Technology, 2001

Selected Publications

  • Shazly T., Baker A., Naber J., Bon A., Van Vliet K., and Edelman E.R., "Augmentation of post-swelling surgical sealant potential of adhesive hydrogels", Journal of Biomedical Materials Research Part A, Accepted
  • Z. Kalcioglu I., Qu M., Strawhecker K., Shazly T., Edelman E.R., VanLandingham M., Smith J., and Van Vliet K, "Dynamic and quasistatic mechanical characterization of hydrated biological tissues and tissue surrogate gels", Philosophical Magazine, Accepted
  • Artzi N.*, Shazly T.*, Baker A., Ramos A., and Edelman E.R., "Aldehyde-amine chemistry enables modulated biosealants with tissue-specific adhesion", Advanced Materials, 32-33 (2009) pp 3399-3403 (*Indicates equal author contribution)
  • Baker A., Groothuis A., Jonas M., Ettenson D., Shazly T., Zcharia E., Vlodavsky I., Seifert P., and Edelman E.R., "Heparanase alters arterial structure, mechanics and repair following endovascular stenting in mice", Circulation Research, 104(3): (2009) pp. 380-387
  • Artzi N., Shazly T., Crespo C., Ramos A., Chenault H., and Edelman E.R., "Characterization of star adhesive sealants based on PEG:dextran hydrogels", Macromolecular Bioscience, 9(8), (2009) pp 754-765
  • Shazly T., Artzi N., Boehning F., and Edelman E.R, "Viscoelastic adhesive mechanics of aldehyde-mediated soft tissue sealants", Biomaterials, 29 (2008) pp. 4584-4591