Research in Professor Chao’s Group

Bio-medical studies :

Cranial suture morphology evolution  -- why and how the cranial suture develops from simple, straight line to very complex zig-zag patterns as one matures ?

Effect of drugs (e.g. Granulocyte Colony Stimulating Factor (G-CSF) ) on the change of biological properties of bones, organs, tissue, etc.

Effect of mechanical stimuli on the growth of cranial suture and bones.

 

                                                                 

 

 

Representative Publications

  1. Wu, Yii-Der, Chien, Chi-Hui, Chao, Yuh J., Hill, William D.,  Yu, Jack, and Li, Xiaodong, “Granulocyte Colony Stimulating Factor (G-CSF) Treatment Alters Femoral Biomechanical Properties in C57BL/6 Mice,” to appear in  Journal of Biomedical Materials Research: Part A. 

  2. Chien, C.H., Wu, Yii-der and Chao, Y.J., T. Chen, and W.F. Chen, “The Effects of Different Cranial Size on Mechanical Properties of Cranial Suture in Rat and Same-aged Mice,”   Strain, to appear.

  3. Wu, Yii-Der, Chien, Chi-Hui, Chao, Yuh J., Yu, Jack C. and Williamson, Mathew, “Fourier Analysis of Human Sagittal Sutures,” The Cleft Palate-Craniofacial Journal, September 2007, Vol.44, No.5, 482-493.

  4. Li,  Xiaodong,  An, Yuehuei H.,  Wu, Yii-Der, Song, Ying Ching,  Chao, Yuh J., and Chien, Chi-Hui,  “A Microindentation Test for Assessing the Mechanical Properties of Cartilaginous Tissues,” Journal of Biomedical Materials Research, Part B, Applied Biomaterials, in press. 

  5.  Hamrick,  Mark W.,  Ding, Ke-Hong,  Pennington1, Catherine, Chao,  Yuh J., Wu, Yii-Der, Howard, Boyd, Immel, D., Borlongan, C. M., Paul L., Bollag, W., Walton W. C., Yu, Jack,  Isales,  Carlos M., “Age-Related Loss of Muscle Mass and Bone Strength in Mice is Associated with a Decline in Physical Activity and Serum Leptin,” Bone, 39 (2006) 845-853.

 

Text Box:     Cranial suture of adults Text Box: Cranial suture of infants

                      For questions, send email to chao@sc.edu  or visit http://www.me.sc.edu/fs/chao.html